Respiratory tract infections in dogs pose a significant problem and often require prolonged treatment. The effectiveness of pharmacological therapy can be improved through the administration of nebulized compounds to liquidize mucus and promote its evacuation from the respiratory tract. The aim of this study was to evaluate the effectiveness of nebulized 0.9% NaCl in dogs with respiratory tract infections. Respiratory functions were assessed based on the results of arterial blood gas analyses, and the patients’ clinical status was determined by evaluating the severity of symptoms on a point grading scale. Inhalation of nebulized 0.9% NaCl significantly accelerated improvement in the patents’ clinical status (normalization of body temperature, decreased cough frequency, decrease/elimination of nasal and ocular discharge, improved appetite) and improved pulmonary gas exchange by reducing partial pressure and total content of carbon dioxide and increasing partial pressure and total content of oxygen in blood.
Shariati M, Willaert W, Ceelen W, De Smedt SC, Remaut K. Aerosolization of nanotherapeutics as a newly emerging treatment regimen for peritoneal carcinomatosis. Cancers (Basel). 2019; 11: E906: PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31261685
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Eleanor CH. Small Animal Internal Medicine, Blood Gas Analysis. 4th ed. 2009; 267–283.
Yin ZJ, Jin FG, Xie YH. Influence of gas inhalation with different oxygen contents on the changes of blood gas in arterial blood and cerebrospinal fluid of dogs in plateau. Chin J Clin Rehab. 2005; 9: 102-104.
Kiers HD, Scheffer GJ, Van Der Hoeven JG, Eltzschig HK, Pickkers P, et al. Immunologic consequences of hypoxia during critical illness. Anesthesiology. 2016; 125: 237-249. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27183167
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Bexfield NH, Foale RD, Davison LJ, Watson PJ, Skelly BJ, et al. Management of 13 cases of canine respiratory disease using inhaled corticosteroids. J Small Anim Prac. 2006; 47: 377-382. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16842273
Boyle TE, Hawkins EC, Davis JL, Robertson ID. Failure of nebulized irritant, acidic, or hypotonic solutions or external mechanical stimulation of the trachea to consistently induce coughing in healthy, awake dogs. Canad J Vet Res. 2011; 75: 228-232. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22211000
Dicpinigaitis PV, Morice AH, Birring SS, McGarvey L, Smith JA, et al. Antitussive drugs-past, present, and future. Pharm Rev. 2014; 66: 468-512. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24671376
Bennett WD, Wu J, Fuller F, Balcazar JR, Zeman KL, et al. Duration of action of hypertonic saline on mucociliary clearance in the normal lung. J Appl Physiol (1985). 2015; 118: 1483-1490. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25911685
Main E, Grillo L, Rand S. Airway clearance strategies in cystic fibrosis and non-cystic fibrosis bronchiectasis. Semin Respir Crit Care Med. 2015; 36: 251-266. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25826592
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Chow KE, Tyrell D, Yang M, Abraham LA, Anderson GA. Scintigraphic Assessment of Deposition of Radiolabeled Fluticasone Delivered from a Nebulizer and Metered Dose Inhaler in 10 Healthy Dogs. J Vet Int Med. 2017; 31: 1849-1857. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28961322
Babaei H, Dabiri S, Pirkashani L.M, Mohsenpour H. Effects of salbutamol on the treatment of transient tachypnea of the newborn. Iran J Neon Open Acc. 2019; 10: 42-49.
Chandel A, Goyal AK, Ghosh G, Rath G. Recent advances in aerosolised drug delivery. Biomed Pharmacother. 2019; 112: 108601.PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30780107
Lim BA, Lopez A, Buensalido JA. Refractory Burkholderia cepacia bacteraemia from a consolidation pneumonia lasting more than 7 weeks, successfully treated with systemic. BMJ Case Rep. 2019; 12. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31377717
Lin Y, Chang RYK, Britton WJ, Morales S, Kutter E, et al. Inhalable combination powder formulations of phage and ciprofloxacin for P. aeruginosa respiratory infections. Eur J Pharm Biopharm. 2019; 142: 543-552. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31398437
Lvovschi VE, Joly J, Lemaire N, Maignan M, Canavaggio P, et al. Nebulized versus intravenous morphine titration for the initial treatment of severe acute pain in the emergency department: Study protocol for a multicenter, prospective randomized and controlled trial, CLIN-AEROMORPH. Trials Op Acc. 2019; 20.
Schulz BS, Kurz S, Weber K, Balzer HJ, Hartmann K. Detection of respiratory viruses and Bordetella bronchiseptica in dogs with acute respiratory tract infections. Vet J. 2014; 201: 365–369. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24980809
Romano TG, Correia MDT, Mendes PV, Zampieri FG, Maciel AT, et al. Metabolic acid-base adaptation triggered by acute persistent hypercapnia in mechanically ventilated patients with acute respiratory distress syndrome. Rev Bras Ter Intensiva. 2016; 28: 19-26. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27096672
Nagy O, Seidel H, Paulíková I, Mudroň P, Kováč G. Use of blood gases and lactic acid analyses in diagnosis and prognosis of respiratory diseases in calves. Bul Vet Inst Pulawy. 2006; 50: 149-152.
Pomianowski A, Kuleta Z, Stopyra A, Sobiech P. Badania parametrów równowagi kwasowo-zasadowej we krwi tętniczej, żylnej i włośniczkowej psów zdrowych. Med Wet. 2004; 60: 519-522.
Aromaa M, Lilja-Maula L, Rajamaki MM. Assessment of welfare and brachycephalic obstructive airway syndrome signs in young, breeding age French Bulldogs and Pugs, using owner questionnaire, physical examination and walk tests. Anim Welf. 2019; 28: 287-298.
Darcy HP, Humm K, Ter Haar G. Retrospective analysis of incidence, clinical features, potential risk factors, and prognostic indicators for aspiration pneumonia in three brachycephalic dog breeds. J Am Vet Med. 2018; 253: 869-876.
Davis MS, Cummings SL, Payton ME. Effect of brachycephaly and body condition score on respiratory thermoregulation of healthy dogs. J Am Vet Med Ass. 2017; 251: 1160-1165. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29099251
Fawcett A, Barrs V, Awad M, Child G, Brunel L, et al. Consequences and management of canine brachycephaly in veterinary practice: perspectives from Australian veterinarians and veterinary specialists. Anim Open Acc. 2019; 9: 3. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30577619
Honey L. Future health and welfare crises predicted for the brachycephalic dog population. Vet Rec. 2017; 181: 550.
Chow KE, Tyrell D, Yang M, Abraham LA, Anderson GA. Scintigraphic Assessment of Deposition of Radiolabeled Fluticasone Delivered from a Nebulizer and Metered Dose Inhaler in 10 Healthy Dogs. J Vet Int Med. 2017; 31: 1849-1857. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28961322
Dos Santos Filho M, Hainfellner D, Do Amaral Mendononca D, De Oliveira Folha MRV, Alberigi BRS, et al. Nebulization with sodium chloride solution (0,9%) in the treatment of chronic canine bronchitis. Ac Vet Bras. 2017; 11: 90-92.
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Ekpenyong CE*, Patrick ES and Akpan KSEkpenyong CE*,Patrick ES,Akpan KS. Changes in Serum Markers of Atherogenesis and Hematological Profile after the consumption of Quail eggs. Arch Food Nutr Sci. 2017: doi: 10.29328/journal.afns.1001001; 1: 001-011
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